References
All of the depicted reference compounds were made as a part of a research undertaken during Pavol Jakubec’s PhD studies in Bratislava, an industrial stay at Degussa (Hanau, Germany) and post-doctoral stays at the University of Manchester and the University of Oxford. For further details, see individual research papers, and Pavol Jakubec’s Linked-in profile.
biological active compounds
Manzamine A
- anti-HIV-1, anti-inflammatory, anti-tumour activities, anti-bacterial, anti-fungal, potent anti-malarial activities
manzamine c
- anti-malarial activities
nakadomarin A
- cytotoxic – L1210, antimicrobial activity against a Gram-positive bacterium – Corynebacterium xerosis
Ircinol A
- exhibits antimalarial activity against both chloroquine-sensitive and resistant strain of P. falciparum
Ircinal A
- documented antimalarial activities
Solithromycin
- ketolide antibiotic undergoing clinical development for treatment of community-acquired pneumonia and other infections
Aminoacids
- isolated in > 95% ee
- isolated in > 95% ee
- isolated in > 95% ee, > 95% dr
- isolated in > 95% ee
– isolated in > 95% ee
– isolated in > 95% ee
– isolated in > 95% ee
heterocycles
Isolated as single diastereomer by 1H NMR.
Diastereomeric ratio 98:2
Diastereomeric ratio 97:3
Isolated as single diastereomer by 1H NMR
Isolated as single diastereomer by 1H NMR